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Core Nutrients

High-Potency Multivitamin

When you're eating less, gaps are inevitable.

High-Potency Multivitamin

Beyond the basic idea of a nutritional safety net, it helps to know that GLP-1 users are often "overfed but undernourished" — meaning carrying extra weight while still running low on key nutrients — even before their first dose, frequently starting therapy with undiagnosed shortfalls in vitamins A, E, and C, plus minerals like zinc and selenium. Once treatment begins, the medication's effect on appetite and digestion adds a steady, building risk; for example, GLP-1 users have a 49% higher chance of developing a Vitamin D deficiency compared to people on other weight-loss drugs. Because shortfalls in nutrients like zinc and selenium tend to worsen the longer someone stays on the medication, a consistent daily multivitamin is needed to help prevent longer-term complications — like thyroid dysfunction (meaning an under- or overactive thyroid gland) and poor wound healing — that may not surface until months into your journey.

The case for a daily multivitamin is strengthened by some striking real-world data: about 12.7% of GLP-1 users develop a brand-new, measurable nutritional deficiency within just six months. This risk isn't only from eating smaller portions; the medication's physical effects — like slowed gastric emptying (meaning food leaves your stomach more slowly) and side effects such as persistent nausea or diarrhea — can both limit how well your body absorbs nutrients and speed up how fast you lose them. Without the broad-spectrum backup of a multivitamin, your body is short on the cofactors (helper nutrients that make chemical reactions work) it needs to keep your metabolism healthy, which can contribute to a "skinny fat" outcome where up to 40% of the weight you lose is lean muscle rather than fat. A proactive supplement plan helps make sure your body has the micronutrients it needs to support a healthy metabolism and hold onto physical strength during rapid weight loss.

Deep dive

Why a Multi Matters on GLP-1s

When you cut your food intake dramatically — which is the entire point of a GLP-1 — you also cut your intake of vitamins and minerals. Over weeks and months, these deficiencies accumulate and can surface as fatigue, hair thinning, brain fog, or weakened immunity. A high-potency multivitamin acts as nutritional insurance, filling in the gaps that a reduced diet leaves behind. It's not a replacement for food, but it's a smart safety net.

What to Look For

Choose a multivitamin with bioavailable forms of nutrients — methylfolate (not folic acid), methylcobalamin (B12), and chelated minerals. Look for one that includes iron and zinc if your labs show you're low, or skip iron if they don't. Avoid gummy vitamins if possible; they often contain added sugar and lower potencies. A good multi will have 100% or more of the daily value for most nutrients in a single serving.

When to Take It

Take your multivitamin with food — ideally your largest meal of the day — to improve absorption and reduce stomach upset. If you take a separate magnesium or iron supplement, space them at least 2 hours apart from your multi, as some minerals compete for absorption. Bring your multivitamin bottle to your next appointment so your clinician can review it against your latest labs.

Sources
  1. practicalgastro.com — https://practicalgastro.com/wp-content/uploads/2026/06/Nutrition-May-2026.pdf
  2. vikingalternative.com — https://vikingalternative.com/glp-1-vitamin-deficiency-what-your-ozempic-doctor-isnt-telling-you/

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