Omega-3 Fatty Acids

Your GLP-1 and a good fish oil make a quietly powerful team — especially for your heart. Triglycerides are a kind of fat floating in your blood; when they climb too high, they nudge up your risk of heart trouble, so bringing them down is a genuine win. On its own, your medication typically lowers them by about 10–20%. Add 2–4 grams of omega-3s a day and you can trim them another 15–30% — which can stack up to a 30–50% drop overall. Omega-3s go beyond simply dialing down inflammation, too: your body turns them into resolvins and protectins, special messengers that actively help calm and close out inflammation rather than just mute it. A quick note on the numbers, since they can look like alphabet soup: blood pressure is measured in "millimeters of mercury," usually written as mmHg — it's the same unit you see on a reading from the doctor's office or a home cuff, where a healthy adult often lands around 120/80. The small 2–5 mmHg dip from omega-3s layers onto the 3–6 mmHg that often comes with GLP-1-driven weight loss, and for some people that's enough to settle into a healthier range without adding another medication.

There's also promising research on omega-3s protecting what you might think of as your "metabolic engine" — meaning the muscle and strength you want to keep while the weight comes off, because that muscle is what burns calories for you day in and day out. In studies, supplementation has improved thigh muscle volume and handgrip strength, likely through those same anti-inflammatory pathways. They matter for your gallbladder, too: omega-3s help keep it from getting sluggish (a slowdown that raises the risk of gallstones), a real concern when weight is dropping fast on medications like Ozempic or Wegovy. One friendly safety note: high doses (above 3 grams a day) can raise bleeding risk, particularly if you're on blood thinners, and you'll want to pause fish oil 1–2 weeks before any planned surgery.